Invention:
A University of Arizona researcher has invented a polyclonal antibody against a novel phosphorylation site that is known to be correlated with increased tumor growth. Specifically, the antibody targets a phosphorylation site on HIF-1α, which is controlled by PIM kinases.
Background:
Anti-angiogenic therapy is a new and promising strategy for combatting solid cancers such as myeloma, leukemia, prostate and breast cancer. Angiogenesis is considered a hallmark indicator of tumorigenesis and is believed to be required for tumor growth and metastasis. HIF-1 is a master regulator gene involved in the cellular response to hypoxia.
In attempting to develop effective treatments against solid cancers, it has been shown that prolonged activation of HIF-1 is associated with greater resistance to anti-angiogenic agents. Thus, this invention is a promising approach because it is an antibody that targets the phosphorylation site on HIF-1α to prevent phosphorylation by PIM kinase, thus reducing HIF-1 master regulator activation and ultimately, decreasing resistance to anti-angiogenic drugs.
Applications:
Advantages:
- Reduce resistance to and increase efficacy of anti-angiogenic drugs
- Can be used to test the efficacy of PIM kinase inhibitors and anti-angiogenic drugs
