Invention:
This invention is a set of novel synthetic compounds that demonstrate autophagy-inhibiting efficacy, useful for cancer and pulmonary hypertension treatment.
Background:
Autophagy is an evolutionarily conserved lysosomal protein degradation process. Aberrant autophagy plays a role in the pathogenesis of many health conditions including cancer, pulmonary hypertension, diabetes, neurodegenerative disorders, and others. This technology is directed to a series of novel therapeutic compounds that inhibit autophagy.
Applications:
- Autophagy inhibitors for cancer
- Autophagy inhibitors for pulmonary hypertension
Advantages:
- Novel
- Potential to slow disease pathogenesis
- Ability to treat a wide array of pulmonary arterial hypertension (PAH)
