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Novel Diazeniumdiolate-Based Aspirin Prodrugs for Cancer Treatment

A compound has been developed for releasing controlled fluxes of HNO in physiological media or conditions. The compound undergoes a slow hydrolysis at physiological pH, such that it generates a correspondingly lower steady-state concentration of HNO, minimizing its dimerization/dehydration to N2O. As a result the compound can provide increased efficacy...

Published: 3/12/2024 | Inventor(s): Katrina Miranda, David Wink, Jr., Debashree Basudhar

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Category(s): Technology Classifications > Healthcare Portfolios > Oncology

Production of HNO from Derivatized Diazeniumdiolates

A compound has been developed for releasing controlled fluxes of HNO in physiological media or conditions by researchers at the University of Arizona. The compound undergoes a slow hydrolysis at physiological pH, such that it generates a correspondingly lower steady-state concentration of HNO, minimizing its dimerization/dehydration to N2O. As a result...

Published: 3/12/2024 | Inventor(s): Katrina Miranda, Debra Salmon

Keywords(s):

Category(s): Technology Classifications > Materials, Technology Classifications > Materials > Chemicals