Acoustic Radiation Force Impulse Procedures for Modulating Glial Cells and Neurons in the Central Nervous System

This technology leverages focused ultrasound and Acoustic Radiation Force Impulse (ARFI) techniques to improve brain health by normalizing synaptic activity and enhancing waste clearance in the central nervous system. It provides two non-invasive procedures: one targets astrocytes to modulate synaptic activity, while the other stimulates the glymphatic system to improve the removal of harmful waste from the brain. These approaches are designed to address a range of brain disorders, offering potential therapeutic benefits without invasive surgery or drugs.

Background: 
The invention addresses synaptic dysfunction and waste accumulation in the brain, which are major contributors to disorders such as Alzheimer's, Parkinson's, epilepsy, autism, and schizophrenia. Current treatments for these conditions often involve invasive procedures or pharmaceutical approaches, which can have side effects or limited efficacy. This technology differs by providing a non-invasive, mechanical means of improving synaptic and glymphatic function, directly targeting the underlying physiological issues. Unlike existing methods, it uses focused ultrasound to stimulate specific brain regions, offering a more localized and controlled intervention. 

Applications: 

• Neurology and brain disorder therapeutics
• Treatment of neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s)
• Management of psychiatric disorders (e.g., schizophrenia, autism, depression)
• Enhancement of cognitive health and brain waste clearance

Advantages: 

• Non-invasive method 
• Targeted approach with precise stimulation to specific brain regions
• Addresses both synaptic activity and waste clearance
• Adaptable to different brain disorders
• Safer alternative compared to more invasive treatment methods