Fluorophore-Doped Metal-Organic Frameworks for Quantifying Low-Energy Radionuclides in Aqueous Solutions

Case ID:
UA24-025
Invention:

This technology represents a new class of scintillation materials based on metal organic frameworks (MOFs), highly crystalline and tunable structures, which may provide higher detection efficiency compared to other particle scintillation materials. Furthermore, the use of fluorophores with these MOFs paves the way for more versatile applications in the realm of radioisotope detection. The unique combination enhances signal clarity, reducing background noise and increasing overall sensitivity. This breakthrough has the potential to revolutionize methods and protocols in research fields requiring precise radioisotope detection.

Background: 
Radioisotopes are used in clinical diagnosis, therapy of various medical conditions, environmental analyses, nuclear systems, and research in both the physical and life sciences. This involves the investigation of low-energy radiation emitting atoms in chemical solutions. To investigate these, however, requires techniques of detection that are currently cumbersome or unreliable. This is due to the inherent low energy emission making the atoms hard to detect in the first place as well as their weak emissions being unable to penetrate through much of the solution. 

The method described here is a novel and tunable chemical platform that provides a new strategy to detect low energy radioisotopes in aqueous solutions. The tunable platform enables highly efficient detection compared to other materials. Traditional methods of investigation require techniques of detection that are currently cumbersome or unreliable. Challenges arise due to the inherent low energy emission making the atoms hard to detect in the first place, compounded by their weak emissions being unable to penetrate through much of the solution. The fluorophore-doped MOF approach outlined in this technology not only addresses these challenges but offers a superior alternative.

Applications: 

  • Radioisotope detection and measurement
    • Medical diagnostics
    • Therapeutics
    • Environmental analyses
    • Nuclear systems analyses
    • Research

Advantages: 

  • Increased efficiency
  • Enhanced doping homogeneity
  • Enhanced precision
Patent Information:
Contact For More Information:
Jonathan Larson
Senior Licensing Manager, College of Science
The University of Arizona
jonathanlarson@arizona.edu
Lead Inventor(s):
Craig Aspinwall
Chen-Yi Ke
Brian Zacher
Keywords: