Invention:
This mass spectrometry analysis software and method extends the UniDec Bayesian deconvolution algorithm for application to rapid analysis of biotherapeutics, including determining the drug-to-antibody ratio for antibody-drug conjugates and calculating the correct pairing of bispecific antibodies.
Background:
Mass spectrometry (MS) and intact mass analysis are increasingly common in academic and industry research. This has created a demand for more robust approaches to MS analysis. UniDec is one approach. UniDec is a software package based on a Bayesian deconvolution algorithm. The algorithm provides a rapid and robust approach to deconvolving electrospray mass spectra into their corresponding mass and charge components.
Applications:
- Mass spectrometry analysis
- Biomolecules
- Antibody-drug conjugates
Advantages:
- Streamlines analysis for antibody-drug conjugates
- Improves data quality
- Removes deconvolution artifacts
