Invention:
This invention is a novel way to create Alternative Igs (AltIgs). This invention could be used to fuse two proteins together as a single polypeptide by fusing the AltIg end of one protein to the other protein. This would create a different spatial relationship between the proteins than could be achieved if the native Ig was fused in a conventional manner.
Background:
Fusing two proteins into a polypeptide can present engineering challenges when done in a traditional way because often it leaves the functional ends of the proteins in sub-optimal positions. This technology helps overcome this challenge by creating a new spatial relationship between the proteins. This technology can be used as a therapeutic reagent to attack tumor cells, making it a promising cancer treatment.
Applications:
- Create therapeutic reagents
- Create recombinant proteins
- Tumor treatment
Advantages:
- Efficient use of multi-functional polypeptides
- Greater utilization of protein function
- Versatile product with numerous applications
