Invention:
In this invention, an external stimulus is applied to the stationary phase of liquid chromatography to alter the polarity of the solvent during a separation process. This capability enables improved separations with more efficient use of mobile phase. The chromatographic separation method can be designed with flexible equipment and machine learning.
Background:
Chromatography is a well-established process and is widely used for laboratory chemical separation; however, it is problematic for large scale use. Enhancements in separation efficiency will be useful to many areas of research and industry including:
- Pharmaceutical active ingredients
- Fine chemicals
- Environmental separations
- Life sciences
- Separations of complex mixtures
Applications:
- Compound purification and/or chemical separations
Advantages:
- Improved performance in chromatography separations
- Increased resolution
- More efficient use of mobile phase
- Less waste
- Can enable commercial scale separations
