Invention:
This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease.
Background:
Alzheimer’s disease (AD) is the most common form of dementia estimated to affect 36 million people worldwide and an estimated 115 million people by 2050. While doctors still don’t know the cause of AD, treatments for the degenerative disease are in high demand. The inventors have applied computational approaches to existing rich data sets generated by the Accelerating Medical Partnership-Alzheimer's disease consortia to discover novel targets. Two natural compounds have shown beneficial effects in neuronal and microglial cell cultures. They are validated to protect neurons from cell death and unregulated microglia phagocytic activity.
Applications:
- Alzheimer's treatment and prevention
Advantages:
- Prevent cell death
- neuronal and microglial cell application
