Invention:
This invention is the discovery of lead ligands, LYS739 and LYS744, for the treatment of chronic pain including neuropathic pain. These are single compounds representing a novel therapeutic pathway to improve analgesic efficacy.
Background:
Chronic pain is poorly managed with current medications because long term administration or higher doses may increase the potential for addiction and adverse effects such as respiratory depression. Chronic pain is known to up-regulate kappa opioid receptors, causing a diminished analgesic effect from mu opioid receptor agonists. A single molecule with the ability to target multiple opioid receptors would allow the use for lower doses and decrease adverse effects.
Applications:
- Pharmaceutical companies
- Biotechnology companies
- Diagnostic assay companies
- Research centers
- Academic laboratories
Advantages:
- High efficacy
- Reduces adverse effects
- Able to penetrate blood brain barrier
- Improves bioavailability with lipophilic moiety
