Pharmacogenomics of Intergenic SNPs and in Silico Modeling for Precision Therapy

Case ID:
UA16-224
Invention:

This invention is a method for analyzing a single patient’s DNA and modeling how mutations and variations in intra-cell genomics will be expressed in the body. The information may be used to develop highly personalized therapies without the need for huge experimental data sets.

 

Background:
Personalized medicine is the next frontier in therapeutics. Unfortunately, highly specific therapies are virtually incompatible with traditional research methods, which focus on generalized efficacy in cohort-level studies. Because of this, inventors at the University of Arizona sought to create a method that personalized therapeutic profiles using data from only the individual patient. Without the need for cohort-level data, therapies can be more efficiently tailored to a patient's genome and, more importantly, the specific effects of the disease on their genome and vice versa.

 

Applications:

  • Target critical pathways for drug therapies
  • Development of personalized medicine based on personal genetic mutations/variations
  • Research links between genetic variations and disease pathologies

 

Advantages:

  • Employs single-subject data analysis by only requiring information about the patient
  • Capable of using as few as two disease-affected cells
  • Considers intra-cellular genetic heterogeneity
  • Accounts for cell-to-cell variations and how these variations affect gene expression in the body as a whole
Patent Information:
Contact For More Information:
Garrett Edmunds
Licensing Manager, UAHS-TLA
The University of Arizona
gedmunds@arizona.edu
Lead Inventor(s):
Yves Lussier
Ikbel Achour
Joanne Berghout
Haiquan Li
Keywords: